SELECT PUBLICATIONS

2024

Kocabiyik, O., Amlashi, P., Vo, A.L., Suh, H., Rodriguez-Aponte, S.A., Dalvie, N.C., Love, J.C., Andrabi, R. & Irvine, D.J. Vaccine targeting to mucosal lymphoid tissues promotes humoral immunity in the gastrointestinal tract. Sci. Adv. 10 (2024).

Hao, L., Boehnke, N., Elledge, S.K., Harzallah, N-S., Zhao, R.T., Cai, E., Feng, Y.X., Neaher, S., Fleming, H.E., Gupta, P.B., Hammond, P.T. & Bhatia, S.N. Targeting and monitoring ovarian cancer invasion with an RNAi and peptide delivery system. PNAS 121 (2024).

Bhatia, S.N. & Dahlman, J.E. RNA Delivery Systems. PNAS 121 (2024).

Van Heest, A.E., Deng, F., Zhao, R.T., Harzallah, N.S., Fleming, H.E., Bhatia, S.N. & Hao, L. CRISPR-Cas-mediated Multianalyte Synthetic Urine Biomarker Test for Portable Diagnostics. J Vis Exp. 8 (2023).

Martin-Alonso , C.,* Tabrizi, S.,* Xiong, Kan, Blewett, T., Sridhar, S., Crnjac, A., Patel, S., An, S., Bekdemir, A., Shea, D., Wang, S-T, Rodriguez-Aponte, S., Naranjo, C.A., Rhoades, J., Kirkpatrick, J.D., Fleming, H.E., Amini, A.P., Golub, T.R., Love, J.C., Bhatia, S.N., Adalsteinsson, V.A. Priming agents transiently reduce the clearance of cell-free DNA to improve liquid biopsies. Science 383 (2024).

Zhong, Q.,* Tan, E.K.W.,* Martin-Alonso, C., Parisi, T., Hao, L., Kirkpatrick, J.D., Fadel, T.R., Fleming, H.E., Jacks, T., & Bhatia, S.N. Inhalable point-of-care urinary diagnostic platform. Sci. Adv. 10 (2024).

*These authors contributed equally to this work.

2023

Kataria, S., Qi, J., Lin, C-W., Li, Z., Dane, E.L. Mahadevan, A., Sacane, I.J., Irvine, D.J. & Belcher, A.M. Noninvasive In Vivo Imaging of T-Cells during Cancer Immunotherapy Using Rare-Earth Nanoparticles. ACS Nano 17,17908–17919 (2023).

Li, B., Jiang, A.Y., Raji, I. et al. Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA. Nat. Biomed. Eng (2023).

Ma, L., Hostetler, A., Morgan, D.M., Maiorino, L., Sulkaj, I., Whittaker, C.A., Never, A., Piers, I.S., Yousefpour, P., Gregory, J., Qureshi, K., Dye, J., Abraham, W., Sun, H., Li, N., Love, J.C., and Irvine, D.J. Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity. Cell 186, 3148–3165 (2023).

Guimarães, P.G.,* Figueroa-Espada, C.G.,* Riley,R.S., Gong, N., Xue, L., Sewastianikd, T., Dennis, P.S., Loebelf, C., Chungg, A., Shepherd, S.J., Haley, R.M., Hamilton, A.G., El-Mayta, R., Wang, K., Langer, R., Andersong, D.G., Carrascod, R.D., and Mitchell, M.J. In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy. PNAS 120, e2215711120 (2023).

Zhang, A.Q., Hostetler, A., Chen, L.E. et al. Universal redirection of CAR T cells against solid tumours via membrane-inserted ligands for the CAR. Nat. Biomed. Eng (2023).

Pires, I.S., Ni, K., Melo, M.B., Li, N., Ben-Akiva, E., Maiorino, L., Dye, J., Rodrigues, K.A., Yun, D., Kim, B., Hosn, R.R., Hammond, P.T., Irvine, D.J. Controlled lipid self-assembly for scalable manufacturing of next-generation immune stimulating complexes. Chemical Engineering Journal 464, 142664 (2023).

Rhym, L.H., Manan, R.S., Koller, A. Stephanie, G. & Anderson, D.G. Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery. Nat. Biomed. Eng 7, 901–910 (2023)

Raimondo, T.M., Reed, K., Shi, D., Langer, R. & Anderson, D.G. Delivering the next generation of cancer immunotherapies with RNA. Cell 186, 1535–1540 (2023).

Hao, L., Zhao, R.T., Welch, N.L. et al. CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics. Nat. Nanotechnol. 18, 798–807 (2023).

He, Y., Hong, C., Huang, S. et al. STING Protein-Based In Situ Vaccine Synergizes CD4+ T, CD8+ T, and NK Cells for Tumor Eradication. Adv. Health. Mat. 12, 2300688 (2023).

Bhagchandani, S.H., Vohidov, F., Milling, L.E., Tong, E.Y., Brown, C.M., Ramseier, M., Liu, B., Fessenden, T.B., Nguyen, H.V-T., Kiel, G.R., Won, L., Langer, R.S., Spranger, S., Shalek, A.K., Irvine, D.J., Johnson, J.A. Engineering kinetics of TLR7/8 agonist release from bottlebrush prodrugs enables tumor-focused immune stimulation. Science Advances 9 (2023).

Backlund, C.M., Jalili-Firoozinezhad, S., Kim, B. & Irvine, D.J. Biomaterials-Mediated Engineering of the Immune System. Annual Review of Immunology 41, 153–179 (2023).

Hong, C., He, Y., Bowen, P.A., Belcher, A.M., Olsen, B.D. & Hammond, P.T. Engineering a Two-Component Hemostat for the Treatment of Internal Bleeding through Wound-Targeted Crosslinking. Adv. Healthcare Mater. 12 (2023).

Kim, B. Hosn, R.R., Remba, T., Yun, D., Li, N., Abraham, W., Melo, M.B., Cortes, M., Li, B., Zhang, Y., Dong, Y., & Irvine, D.J. Optimization of storage conditions for lipid nanoparticle-formulated self-replicating RNA vaccines. Journal of Control Release 353, 241–253 (2023).

Aung, A., Cui, A. Maiorino, L., Amini, A.P., Gregory, J.R., Bukenya, M., Zhang, Y., Lee, H., Cottrell, C.A., Morgan, D.M., Silva, M., Suh, H., Kirkpatrick, J.D., Amlashi, P., Remba, T., Froehle, L.M., Xiao, S., Abraham, W., Adams, J., Love, J.C., Huyett, P., Kwon, D.S., Hacohen, N., Schief, W.R., Bhatia, S.N., & Irvine, D.J. Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science 379 (2023).

2022

Barberio, A.E.,* Smith, S.G.,* Pires, I.S., Iyer, S., Reinhardt, F., Melo, M.B., Suh, H., Weinberg, R.A., Irvine, D.J., & Hammond, P.T. Layer-by-layer interleukin-12 nanoparticles drive a safe and effective response in ovarian tumors. Bioengineering & Translational Medicine 379 (2022).

Irvine, D.J., Maus, M.V., Mooney, D.J., & Wong, W.W. The future of engineered immune cell therapies. Science 378 (2022).

Amini, A.P., Kirkpatrick, J.D., Wang, C.S., Jaeger, A.M., Su, S., Naranjo, S., Zhong, Q., Cabana, C.M., Jacks, T., & Bhatia, S.N. Multiscale profiling of protease activity in cancer. Nature Communication 13 (2022).

Backlund, C.M., Holden, R.L., Moynihan, K.D., Garafola, D., Farquhar, C., Mehta, N.K., Maiorino, L., Pham, S., Iorgulescu, J.B., Reardon, D.A., Wu, C.J., Pentelute, B.L., & Irvine, D.J. Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity. PNAS 119 (2022).

Bhatia, S.N., Chen, X., Dobrovolskaia, M.A. & Lammers, T. Cancer nanomedicine. Nature Review Cancer 2022.

Boehnke, N.,* Straehla, J.P.,* Safford, H.C., Kocak, M., Rees, M.G., Ronan, M., Rosenberg, D., Adelmann, C.H., Chivukula, R.R., Nabar, N., Berger, A.G., Lamson, N.G., Cheah, J.H., Li, H., Roth, J.A., Koehler, A.N., & Hammond, P.T. Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery. Science 377 (2022).

Hartwell, B.L., Melo, M.B., Xiao, P., Lemnios, A.A., Li, N., Chang, J.Y.H., Yu, J., Gebre, M.S., Chang, A., Maiorino, L., Carter, C., Moyer, T.J., Dalvie, N.C., Rodriguez-Aponte, S.A., Rodrigues, K.A., Silva, M., Suh, H., Adams, J., Fontenot, J. Love, J.C., Barouch, D.H., Villinger, F., Ruprecht, R.M., & Irvine, D.J. Intranasal vaccination with lipid-conjugated immunogens promotes antigen transmucosal uptake to drive mucosal and systemic immunity. Science Translational Medicine 14 (2022).

Lin, C-W., Huang, S., Colangelo, M., Chen, C., Wong N.C.F., He, Y., Berggren, K. & Belcher, A.M. Surface Plasmon Enhanced Upconversion Fluorescence in Short-Wave Infrared for In Vivo Imaging of Ovarian Cancer. ACS Nano 16, 12930–12940 (2022).

Wamhoff, E.C., Romanov, A., Huang, H., Read, B.J., Ginsburg, E., Knappe, G.A., Kim, H.M., Farrell, N.P., Irvine, D.J., & Bathe, M. Controlling Nuclease Degradation of Wireframe DNA Origami with Minor Groove Binders. ACS Nano 16, 8954-8966 (2022).

Tsedev, U., Lin, C-W., Hess, G.T., Sarkaria, J.N., Lam, F.C., & Belcher, A.M. Phage Particles of Controlled Length and Genome for In Vivo Targeted Glioblastoma Imaging and Therapeutic Delivery. ACS Nano 16, 11676–11691(2022).

Kirkpatrick, J.D., Soleimany, A.P., Dudani, J.S., Liu, H-J., Lam, H.C., Priolo, C., Henske, E.P., & Bhatia, S.N. Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis. European Respiratory Journal 59 (2022).

Crosby D., Bhatia, S.N., Brindle, K.M., Coussens, L.M., Dive, C., Emberton, M., Esener, S., Fitzgerald, R.C., Gambhir, S.S., Kuhn, P., Rebbeck, T.R., & Balasubramanian, S. Early Detection of Cancer. Science 375 (2022).

Bekdemir, A., Tanner, E.E.L., Kirkpatrick, J.D., Soleimany, A.P., Mitragotri, S., & Bhatia, S.N. Ionic Liquid-Mediated Transdermal Delivery of Thrombosis-Detecting Nanosensors. Advanced Healthcare Materials 11 (2022).

Dane E.L., Belessiotis-Richards A., Backlund C., Wang J., Hikada K., Milling L.E., Bhagchandani S., Melo M.B., Wu S., Li N., Donahue N., Ni K., Ma L., Okaniwa M., Stevens M.M., Alexander-Katz A., & Irvine D.J., STING agonist delivery by tumour-penetrating lipid nanodiscs primes robust anticancer immunity. Nature Materials 21, 710–720 (2022).

Agarwal Y., Milling, L.E., Chang, J.Y.H., Santollani, L., Sheen, A., Lutz, E.A., Tabet, A., Stinson, J., Ni, K., Rodrigues, K.A., Moyer, T.J., Melo, M.B., Irvine, D.J., & Wittrup, K.D. Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity. Nature Biomedical Engineering 6, 129–143 (2022).

Milling, L.E., Garafola, D., Agarwal, Y., Wu, S., Thomas, A., Donahue, N., Adams, J., Thai, N., Suh, H., & Irvine, D.J. Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-cell Activation. Cancer Immunology Research 10, 26–39 (2022).

*These authors contributed equally to this work.

2021

Silva, M., Kato, Y., et al. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity. Science Imm. 2021, 6 (66).

Sriram, G., Milling, L.E., Chen, J-K., Kong, Y.W., Joughin, B.A., Abraham, W., Swartwout, S., Handly, E., Irvine, D.J., & Yaffe, M.B. The injury response to DNA damage in live tumor cells promotes antitumor immunity. Science Sign. 2021, 14 (706).

Knappe, G., Wamhoff, E-C., Read, B.J., Irvine, D.J., & Bathe, M. In Situ Covalent Functionalization of DNA Origami Virus-like Particles. ACS Nano. 2021, 15 (9), 14316–14322.

He J., Nissim, L., Soleimany, A.P., Binder-Nissim, A., Fleming, H.E., Lu, T.K., & Bhatia, S.N. Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection. ACS Synth. Biol. 2021, 10 (9), 2231–2242.

Kaczmarek, J.C., Patel, A.K., Rhym, L.H., Palmiero, U.C., Bhat, B., Heartlein, M.W., DeRosa, F., & Anderson, D.G. Systemic delivery of mRNA and DNA to the lung using polymer-lipid nanoparticles. Biomat. 2021, 275, 120966.

Bhagchandani, S., Johnson, J. A., & Irvine, D.J. Evolution of Toll-like receptor 7/8 agonist therapeutics and their delivery approaches: From antiviral formulations to vaccine adjuvants. Adv. Drug. Deliv. Rev. 2021, 175, 113803.

Hao L., Rohani, N., Zhao, R.T., Pulver, E.M., Mak, H., Kelada, O.J., Ko, H., Fleming, H.E., Gertler, F.B., & Bhatia, S.N. Microenvironment-triggered multimodal precision diagnostics. Nat. Mat. 2021, 20, 1440–1448.

Hasan T., Lee, B.H., Lin, C-W., McDonald-Boyer, A., Gonzalez-Rodriguez, R., Vasireddy, S., Tsedev, U., Coffer, J., Belcher, A.M., & Naumov, A.V. Near-infrared emitting graphene quantum dots synthesized from reduced graphene oxide for in vitro/in vivo/ex vivo bioimaging applications. 2D Mat. 2021, 8 (3), 035013.

Pires, I.S., Hammond, P.T., & Irvine, D.J. Engineering Strategies for Immunomodulatory Cytokine Therapies: Challenges and Clinical Progress. Adv. Therap. 2021.

Isidora Tošić, Lisa N. Heppler, Susana P. Egusquiaguirre, Natalie Boehnke, Santiago Correa, Daniel F. Costa, Elizabeth A. Grossman Moore, Sharmistha Pal, Douglas S. Richardson, Alexander R. Ivanov, Daphne A. Haas-Kogan, Daniel K. Nomura, Paula T. Hammond and David A. Frank. Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid–coated Layer-by-Layer Nanoparticles. Mol. Can. Therap. 2021, 20 (4), 726-738.

Kong, S.M., Costa, D.F., Jagielska, A., Van Vliet, K.J., & Hammond, P.T. Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration. PNAS 2021, 118 (42).

Rakhra, K., Abraham, W., Wang, C., Moynihan, K.D., Li, N., Donahue, N., Baldeon, A.D., & Irvine, D.J. Exploiting albumin as a mucosal vaccine chaperone for robust generation of lung-resident memory T cells. Sci. Immunol. 2021, 6 (57), eabd8003.

Samad, T., Fleming, H.E., Bhatia, S.N. Virtual Undergraduate Research Experiences: More Than a Pandemic Stopgap. Med. 2021, 2 (2), 118–121.

He, Y., Hong, C., Irvine, D.J., Li, J., & Hammond, P.T. In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex. Bio-Prot. 2021, 11 (3), 2211–2219.

Soleimany, A.P., Kirkpatrick, J.D., Su, S., Dudani, J.S., Zhong, Q., Bekdemir, A., & Bhatia, S.N. Activatable Zymography Probes Enable In Situ Localization of Protease Dysregulation in Cancer. Can. Res. 2021, 81 (1), 213–224.

Huang, S., Lin, C-W., Qi, J., Mahadevan Iyer, A., He, Y., Li, Y., Bardhan, N.M., Irvine, D.J., Hammond, P.T., & Belcher, A.M. Surface Plasmon‐Enhanced Short‐Wave Infrared Fluorescence for Detecting Sub‐Millimeter‐Sized Tumors. Adv. Mat. 2021, 33 (7), 2006057.

2020

Krohn-Grimberghe, M., Mitchell, M.J., Schloss, M.J., Khan, O.F., Courties, G., Guimaraes, P.G., Rohde, D., Cremer, S., Kowalski, P.S., Sun, Y., Tan, M., Webster, J., Wang, K., Iwamoto, Y., Schmidt, S.P., Wojtkiewicz, G.R., Nayar, R., Frodermann, V., Hulsmans, M., Chung, A., Hoyer, F.F., Swirski, F.K., Langer, R., Anderson, D.G., & Nahrendorf, M.. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat. Biomed. Eng., 2020, 4, 1076–1089.

Li, Y. Su, Z., Zhao, W., Zhang, X., Momin, N., Zhang, C., Wittrup, D.K., Dong, Y., Irvine, D.J., & Weiss, R. Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity. Nat. Canc. 2020, 1, 882–893.

Boehnke, N., Dolph, K.J., Juarez, V.M., Lanoha, J.M., & Hammond, P.T. Electrostatic conjugation of nanoparticle surfaces with functional peptide motifs. Bioconj. Chem. 2020, 31 (9), 2211–2219.

Kwon, E.J., Ko, H., & Bhatia, S.N. Peptide Spiders: Peptide–Polymer Conjugates to Traffic Nucleic Acids. Mol. Pharm. 2020, 17 (9), 3633–3642.

Barberio, A.E., Smith, S.G., Correa, S., Nguyen, C., Nhan, B., Melo, M., Tokatlian, T., Suh, H., Irvine, D.J., & Hammond, P.T. Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery. ACS Nano. 2020, 14 (9), 11238–11253.

Buss, C.G. & Bhatia, S.N. Nanoparticle delivery of immunostimulatory oligonucleotides enhances response to checkpoint inhibitor therapeutics. PNAS. 2020, 117 (24), 13428–13436.

Irvine, D.J., Aung, A., & Silva, M. Controlling timing and location in vaccines. Adv. Drug Deliv. Rev., 2020, 158, 91-115.

Vohidov, F., Milling, L. E., Chen, Q., Zhang, W., Bhagchandani, S., Nguyen, H. V.-T., Irvine, D. J., & Johnson, J. ABC triblock bottlebrush copolymer-based injectable hydrogels: design, synthesis, and application to expanding the therapeutic index of cancer immunochemotherapy. Chem. Sci. 2020, 11 (23), 5974–5986.

Tian, C., Öhlund, D., Rickelt, S., Lidström, T. Huang, Y., Hao, L., Zhao, R.T., Franklin, O., Bhatia, S.N., Tuveson, D.A., & Hynes, R.O. Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma. Can. Res., 2020, 80 (7), 461–1474.

Jiang, T., Henderson, J.M., Coote, K., Cheng, Y., Valley, H.C., Zhang, X., Wang, Q., Rhym, L.H., Cao, Y., Newby, G.A., Bihler, H., Mense, M., Weng, Z., Anderson, D.G., McCaffrey, A.P. Liu, D.R., & Xue, W. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope. Nat Commun. 2020, 11, 1979.

Bardhan N.M. & Belcher A.M. (2020) Polymer-Functionalized NIR-Emitting Nanoparticles: Applications in Cancer Theranostics and Treatment of Bacterial Infections. In: Benayas A., Hemmer E., Hong G., Jaque D. (eds) Near Infrared-Emitting Nanoparticles for Biomedical Applications. Springer, Cham.

Kirkpatrick, J.K., Warren, A.D., Soleimany, A.P., Westcott, M.K., Voog, J.C., Martin-Alonso, C., Fleming, H.E., Tammela, T., Jacks, T., & Bhatia S.N. Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling. Sci. Trans. Med. 2020, 12 (537).

Boehnke, N., Correa, S., Hao, L., Wang, W., Straehla, J.P., Bhatia, S.N., & Hammond, P.T. Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing. Angew. Chem. Int. Ed. 2020, 59, 2776–2219.

Correa, S., Boehnke, N., Barberio, A.E., Deiss-Yehiely, E., Shi A., Oberlton, B., Smith, S.G., Zervantonakis, I., Dreaden, E.C., & Hammond, P.T. Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry. ACS Nano. 2020, 14 (2), 2224–2237.

Schuerle, S., Furubayashi, M., Soleimany, A.P., Gwisai, T., Huang, W., Voigt, C., & Bhatia, S.N. Genetic Encoding of Targeted Magnetic Resonance Imaging Contrast Agents for Tumor Imaging. ACS Synthetic Biology. 2020, 9 (2), 392–401.

Yeom, J., Guimaraes, P. P. G., Ahn, H. M., Jung, B.‐K., Hu, Q., McHugh, K., Mitchell, M. J., Yun, C.‐O., Langer, R., & Jaklenec, A., Chiral supraparticles for controllable nanomedicine. Adv. Mater. 2020, 32, 1903878.

Irvine, D.J. & Dane, E.L., Enhancing cancer immunotherapy with nanomedicine. Nat. Rev. Immunol. 2020, 20, 321–334.

2019

Loynachan, C.N.*, Soleimany, A.P.*, Dudani, J.S., Lin, Y., Najer, A., Bekdemir, A., Chen, Q., Bhatia, S.N., Stevens, M.M. Renal clearable catalytic gold nanoclusters for in vivo disease monitoring. Nat. Nanotech. 2019, 14 (9), 883–890.

Ma, L., Dichwalkar, T., Chang, J. Y. H., Cossette, B., Garafola, D., Zhang, A. Q., Fichter, M., Wang, C., Liang, S., Silva, M., Kumari, S., Mehta, N. K., Abraham, W., Thai, N., Li, N., Wittrup, K. D., & Irvine, D. J. Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor. Science. 2019 365 (6449), 162–168.

Lin, C.-W., Bachilo, S. M., Zheng, Y., Tsedev, U., Huang, S., Weisman, R. B., & Belcher, A. M. Creating fluorescent quantum defects in carbon nanotubes using hypochlorite and light. Nat. Comm. 2019 10 (1), 2874.

Li, Y., Teague, B., Zhang, Y., Su, Z., Porter, E., Dobosh, B., Wagner, T., Irvine, D. J., & Weiss, R. In vitro evolution of enhanced RNA replicons for immunotherapy. Sci. Rep. 2019, 9 (1), 6932.

Huang, S., Qi, J., deQuilettes, D.W., Huang, M., Lin, C., Bardhan, N.M., Dang, X., Bulović, V., and Belcher, A.M. (2019). M13 Virus‐Based Framework for High Fluorescence Enhancement. Small 1901233.

Ceppi, L., Bardhan, N.M., Na, Y., Siegel, A., Rajan, N., Fruscio, R., Del Carmen, M.G., Belcher, A.M., and Birrer, M.J. (2019). Real-Time Single-Walled Carbon Nanotube-Based Fluorescence Imaging Improves Survival after Debulking Surgery in an Ovarian Cancer Model. ACS Nano 13, 5356–5365.

Dang, X., Bardhan, N.M., Qi, J., Gu, L., Eze, N.A., Lin, C.W., Kataria, S., Hammond, P.T., and Belcher, A.M. (2019). Deep-tissue optical imaging of near cellular-sized features. Sci. Rep. 9, 1–12.

Correa, S., Boehnke, N., Deiss-Yehiely, E., and Hammond, P.T. (2019). Solution Conditions Tune and Optimize Loading of Therapeutic Polyelectrolytes into Layer-by-Layer Functionalized Liposomes. ACS Nano 13, 5623–5634.

Xie, Y.-Q., Arik, H., Wei, L., Zheng, Y., Suh, H., Irvine, D.J., and Tang, L. (2019). Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells. Biomater. Sci. 4, 1345–1357

Riley, R.S., June, C.H., Langer, R., and Mitchell, M.J. (2019). Delivery technologies for cancer immunotherapy. Nat. Rev. Drug Discov. 18, 175–196.

Song, C.Q., Jiang, T., Richter, M., Rhym, L.H., Koblan, L.W., Zafra, M.P., Schatoff, E.M., Doman, J.L., Cao, Y., Dow, L.E., et al. (2019). Adenine base editing in an adult mouse model of tyrosinaemia. Nat. Biomed. Eng.

2018

Bisso, P.W., Gaglione, S., Guimarães, P.P.G., Mitchell, M.J., and Langer, R. (2018). Nanomaterial Interactions with Human Neutrophils. ACS Biomater. Sci. Eng. 4, 4255–4265.

Dudani, J.S., Ibrahim, M., Kirkpatrick, J., Warren, A.D., and Bhatia, S.N. (2018). Classification of Prostate Cancer Using a Protease Activity Nanosensor Library. Proc. Natl. Acad. Sci. USA. 115, 8954–8959.

Guimarães, P.P.G., Gaglione, S., Sewastianik, T., Carrasco, R.D., Langer, R., and Mitchell, M.J. (2018). Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano 12, 912–931.

Guimarães, P.P.G., Tan, M., Tammela, T., Wu, K., Chung, A., Oberli, M., Wang, K., Spektor, R., Riley, R.S., Viana, C.T.R., et al. (2018). Potent in vivo lung cancer Wnt signaling inhibition via cyclodextrin-LGK974 inclusion complexes. J. Control. Release 290, 75–87.

Kauffman, K.J., Oberli, M.A., Dorkin, J.R., Hurtado, J.E., Kaczmarek, J.C., Bhadani, S., Wyckoff, J., Langer, R., Jaklenec, A., and Anderson, D.G. (2018). Rapid, Single-Cell Analysis and Discovery of Vectored mRNA Transfection In Vivo with a loxP-Flanked tdTomato Reporter Mouse. Mol. Ther. Nucleic Acids 10, 55–63.

Lam, F.C., Morton, S.W., Wyckoff, J., Vu Han, T.L., Hwang, M.K., Maffa, A., Balkanska-Sinclair, E., Yaffe, M.B., Floyd, S.R., and Hammond, P.T. (2018). Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat. Commun. 9.

Lo, J.H., Hao, L., Muzumdar, M.D., Raghavan, S., Kwon, E.J., Pulver, E.M., Hsu, F., Aguirre, A.J., Wolpin, B.M., Fuchs, C.S., et al. (2018). iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol. Cancer Ther. 17, 2377–2388.

Tang, L., Zheng, Y., Melo, M.B., Mabardi, L., Castaño, A.P., Xie, Y.Q., Li, N., Kudchodkar, S.B., Wong, H.C., Jeng, E.K., et al. (2018). Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat. Biotechnol. 36, 707–716.

2017

Dahlman, J.E., Kauffman, K.J., Xing, Y., Shaw, T.E., Mir, F.F., Dlott, C.C., Langer, R., Anderson, D.G., and Wang, E.T. (2017). Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Proc. Natl. Acad. Sci. 114, 2060–2065.

Yin, H., Kauffman, K.J., and Anderson, D.G. (2017). Delivery technologies for genome editing. Nat. Rev. Drug Discov. 16, 387–399.

Kwon, E.J., Dudani, J.S., and Bhatia, S.N. (2017). Ultrasensitive tumour-penetrating nanosensors of protease activity. Nat. Biomed. Eng.

Mitchell, M.J., Jain, R.K., and Langer, R. (2017). Engineering and physical sciences in oncology: Challenges and opportunities. Nat. Rev. Cancer 17, 659–675.

Mitchell, M.J., Webster, J., Chung, A., Guimarães, P.P.G., Khan, O.F., and Langer, R. (2017). Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat. Commun. 8, 1–13.

Moynihan, K.D., and Irvine, D.J. (2017). Roles for innate immunity in combination immunotherapies. Cancer Res. 77, 5215–5221

Ren, Y., Sagers, J.E., Landegger, L.D., Bhatia, S.N., and Stankovic, K.M. (2017). Tumor-Penetrating Delivery of siRNA against TNFα to Human Vestibular Schwannomas. Sci. Rep. 7.

2016

Kauffman, K.J., Mir, F.F., Jhunjhunwala, S., Kaczmarek, J.C., Hurtado, J.E., Yang, J.H., Webber, M.J., Kowalski, P.S., Heartlein, M.W., DeRosa, F., et al. (2016). Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo. Biomaterials 109, 78–87.